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The following graph shows the mean increases in BMD of the lumbar spine, femoral neck, and trochanter in patients receiving Fosamax 10 mg/day relative to placebo-treated patients at three years for each of these studies. In the long-term studies, reductions from baseline in serum calcium (approximately 2%) and phosphate (approximately 4 to 6%) were evident the first month after the initiation of Fosamax 10 mg. As a result of inhibition of bone resorption, Fosamax 5 and 10 mg/day induced asymptomatic decreases in serum calcium (approximately 1 to 2%) and serum phosphate (approximately 1 to 8%). In osteoporosis treatment studies Fosamax 10 mg/day decreased the markers of bone formation, osteocalcin and bone specific alkaline phosphatase by approximately 50%, and total serum alkaline phosphatase by approximately 25 to 30% to reach a plateau after 6 to 12 months. Fosamax is used to treat the following conditions: Aseptic Necrosis, Osteoporosis, Paget's Disease, Prevention of Osteoporosis. The reduction in serum phosphate may reflect not only the positive bone mineral balance due to Fosamax but also a decrease in renal phosphate reabsorption.

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